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Diabetes Drug ‘Significantly Reverses Memory Loss’ in Mice with Alzheimer’s

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A drug developed for diabetes could be used to treat Alzheimer’s after scientists found it “significantly reversed memory loss” in mice through a triple method of action.

The research, published in Brain Research, could bring substantial improvements in the treatment of Alzheimer’s disease through the use of a drug originally created to treat type 2 diabetes.

Alzheimer’s disease is the most common cause of dementia and the numbers are expected to rise to two million people in the UK by 2051 according to Alzheimer’s Society, who part- funded the research.

Dr Doug Brown, Director of Research and Development at Alzheimer’s Society, said: “”With no new treatments in nearly 15 years, we need to find new ways of tackling Alzheimer’s. It’s imperative that we explore whether drugs developed to treat other conditions can benefit people with Alzheimer’s and other forms of dementia. This approach to research could make it much quicker to get promising new drugs to the people who need them.”

In a maze test, learning and memory formation were much improved by the drug which also:

  • enhanced levels of a brain growth factor which protects nerve cell functioning
  • reduced the amount of amyloid plaques in the brain linked with Alzheimer’s
  • reduced both chronic inflammation and oxidative stress
  • slowed down the rate of nerve cell loss

This is a very positive result for Alzheimers research

For the full article follow the link below.

Alzheimers 

 

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